Aripiprazole Overview: What It Is, How to Use It, and What to Watch For

If you’ve been handed a prescription for aripiprazole, you probably have questions. It’s an antipsychotic that many doctors use for conditions like schizophrenia, bipolar disorder, and major depression. Below we break down the basics, give practical dosing pointers, and point out the side effects that most people notice.

Why Doctors Choose Aripiprazole

Aripiprazole works by balancing dopamine and serotonin in the brain. Unlike older antipsychotics, it’s often called a “partial agonist,” which means it can calm over‑active signals without shutting them down completely. This can lead to fewer movement‑related problems (like tremors) for many patients. Because it’s also approved for mood‑stabilizing, doctors sometimes add it to antidepressants when depression isn’t responding.

Getting the Dose Right

Starting doses are usually low—often 2 mg or 5 mg once a day. Your doctor will increase the amount slowly, watching for any side effects. Most adults end up on 10 mg to 30 mg daily, but the exact number depends on your condition, other meds, and how your body reacts. Take the pill at the same time each day, with or without food. If you miss a dose, take it as soon as you remember—unless it’s almost time for your next dose, then just skip the missed one.

Never double up to make up for a missed pill. Doubling can raise the risk of dizziness, nausea, or even more serious reactions. If you’re switching from another antipsychotic, ask your prescriber how to taper the old drug safely while you start aripiprazole.

Side Effects to Expect (and When to Call the Doctor)

Most people feel a mild headache or an upset stomach in the first few days. This usually fades after a week. Common side effects include:

• Restlessness or feeling jittery (known as akathisia)
• Sleepiness or trouble sleeping
• Weight gain – not as dramatic as some older meds, but it can happen
• Dry mouth
• Occasional dizziness when you stand up quickly

If you notice any of these getting worse, or if you develop fever, muscle stiffness, or trouble moving, contact your doctor right away—these could be signs of a rare but serious reaction called neuroleptic malignant syndrome.

Practical Tips for Safer Use

• Keep a medication list. Write down aripiprazole, the dose, and any other drugs you take. This helps pharmacists catch interactions.

• Stay hydrated. Dry mouth can lead to dental issues, so sip water throughout the day.

• Monitor your weight and blood sugar. Some people gain a few pounds, and a slight rise in glucose is possible. Regular check‑ups keep things in check.

• Avoid alcohol. Mixing alcohol with aripiprazole can boost drowsiness and impair judgment.

• Talk to your doctor before stopping. Stopping suddenly can cause withdrawal symptoms like insomnia, irritability, or a return of your original symptoms.

What About Pregnancy and Breastfeeding?

Research on aripiprazole during pregnancy is limited but generally suggests it’s not a major risk. Still, you’ll need a doctor’s go‑ahead if you’re pregnant or planning to become pregnant. The drug does pass into breast milk, so nursing moms should discuss alternatives with their provider.

Overall, aripiprazole can be a reliable part of a mental‑health plan when taken as prescribed. By starting low, moving up slowly, and watching for side effects, you give yourself the best chance for a smooth experience. Have more questions? Bring them to your next appointment—your doctor can tailor the advice to your specific health picture.